Royal Air Force Typhoon jets have conducted a mission with France's air force in a joint strike on an underground arms cache in Syria operated by the IS group, as stated by the British defence ministry.
The location, pinpointed through reconnaissance, was believed to be containing munitions and bombs, the statement said, and was located in hills just north of the historic site of Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a several approach shafts providing entry to the depot... early reports suggest the objective was successfully hit," the MoD said.
There was no evidence of any civilian impact in the operation on Saturday evening and every plane involved returned to base without incident, the MoD added.
The British jets were assisted by a Voyager tanker plane.
The Islamic State group - also known as Daesh - imposed extremist governance over large swathes of Syria and Iraq prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to operate in unison with our partners, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the area," UK Defence Secretary the minister stated.
British military aircraft have carried out surveillance missions over Syria to "forestall any attempted resurgence" of Islamic State after its routing at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of British forces involved in this operation for their professionalism and their bravery," Healey added. "They were among numerous British personnel stationed over the holidays. This mission, to eliminate militants who pose a risk to our way of life, demonstrates how British military are ready to step up, throughout the year, ensuring Britain's security domestically and influential overseas."
Last December, the United States armed forces executed what it described as a "major assault" on Daesh sites in the country, after an attack claimed the lives of two US troops and a civilian linguist in Palmyra.
The United Nations says IS still boasts between 5,000 and 7,000 combatants in Iraq and Syria.